Organizing my ideas, I came up with this IT Security Cheat Sheet, nothing really important should be missing, but in case drop me a line:
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Know your IT assets, often attackers know them better than you do
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Implement a strong IAM security programme, people are the first weak point
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Establish an IT security baseline and apply it to all your IT assets, no matter what or who
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Evaluate IT security risks from a business perspective and implement IT security measures to manage them; do not trust any IT system by default
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Detect, manage and solve IT security incidents, they happen even if you do not detect them
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Learn from the security incidents and feed the knowledge into the previous steps
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Review and re-implement all steps at least yearly (Governance).